Peculiarities of the germline-restricted chromosome of songbird
In multicellular organisms, all cells of an individual normally contain the same genetic information and cell differentiation is achieved through regulation of gene expression. There are exceptions, however, where, instead of silencing, certain sequences are permanently deleted from the genome. An interesting example of this programmed DNA elimination has been described in songbirds, where a whole chromosome is lost from somatic cells early on in embryo development and is maintained only in the germ cells. In a paper, which has just been published in the prestigious journal Nature Communications, the team of Radka Reifová from the Department of Zoology, with Stephen Schlebusch as the first author, together with other researchers sequenced this chromosome in two closely related songbird species, providing one of the first insights into the importance and evolutionary dynamics of this peculiar chromosome.
Published Aug 02, 2023
