M.Sc. Theses Successfully Defended in the Academic Year 2019/2020

Due to the GDPR guidlelines, the names of the respective students and supervisors are not listed here, only the titles of the respective theses (along with links to them in the Charles University Digital Repository, where you can find all relevant information). The theses are categorized according to the supervisor's institution and, within each institution, are sorted alphabetically. The majority of theses are written in Czech but all have at least an English abstract. Information on the current and past supervisory activities of individual internal members of the Department of Genetics and Microbiology can be found on the websites of the respective Laboratories.

Department of Genetics and Microbiology, Faculty of Science, Charles University

• Analysis of miRNAs in HPV-associated carcinomas
• Detection and characterization of macrophages in the tumors of viral and non-viral etiology
• Development of a technique for gene transfer into T-lymphocytes using polyomavirus structures and the LAH₄ peptide
• Experimental system for production of IL-15 on viral carriers
• Formation of protein granules in differentiated cells of yeast colonies
• Interaction partners of protein eIF4E2 in human cells
• Methods for characterization of persistent state after exposure to selected antibiotics in Staphylococcus aureus
• Mode of action of the 4th generation of antibacterial compounds lipophosphonoxins
• Preparation and characterization of modified viral particles derived from mouse polyomavirus for the transport of genes to increase the efficiency of transduction
• Response of maize lines and hybrids to hypoxia stress depending on plant development
• Targeting of viral nanoparticles to CD44 via hyaluronic acid
• The differences in the virome of different populations of honey bee (Apis mellifera)
• The role of proteins acetylation in life cycle of Polyomaviruses

Institute of Microbiology of the Czech Academy of Sciences

• Assembly, successional development and functioning of microbial communities in deadwood
• Engineering of microbial glycosidases for modifying synthetic potential
• Interaction of the human pathogen Bordetella pertussis with blood serum
• Regulation of mycobacterial transcription
• The importance of bacteria for deadwood decomposition in forest ecosystems

Institute of Biotechnology of the Czech Academy of Sciences

• Practical aspects of single-cell RT-qPCR analysis

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

• Ubiquitin-proteasome system in studies of its inhibition and its utilization in the cell-based assay measuring viral protease activity

Institute of Physiology of the Czech Academy of Sciences

• The role of Pin1 and CDK5 in Alzheimer's disease-linked phosphorylation and spread of CRMP2 pathology in neurons

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences

• The impact of mutant huntingtin on oxidative stress in primary fibroblasts isolated from a new Huntington's disease knock in porcine model

Faculties of Medicine, Charles University

• Analysis of streptomycete isolates carrying a cyclizing aminolevulinate synthase gene
• Colistin resistance in clinically important Enterobacteriaceae
• Genomic analysis of Paenibacillus larvae and its relation to virulence
• Nutrigenetic analysis of metabolic syndrome: the role of spontaneously hypertensive rat chromosome 4

Other Departments of the Faculty of Science, Charles University

• Microbial community in sediments of a stream contaminated by pharmaceuticals
• Role of exosomes and ectosomes in Trichomonas vaginalis virulence