M.Sc. Theses Successfully Defended in the Academic Year 2018/2019

Due to the GDPR guidlelines, the names of the respective students and supervisors are not listed here, only the titles of the respective theses (along with links to them in the Charles University Digital Repository, where you can find all relevant information). The theses are categorized according to the supervisor's institution and, within each institution, are sorted alphabetically. The majority of theses are written in Czech but all have at least an English abstract. Information on the current and past supervisory activities of individual internal members of the Department of Genetics and Microbiology can be found on the websites of the respective Laboratories.

Department of Genetics and Microbiology, Faculty of Science, Charles University

• Analysis of antibody response during BK virus infection
• Analysis of sex chromosomes and gene clusters in selected mygalomorph and araneomorph spiders
• Changes in the ability to form persisters in chronological isolates of Staphylococcus aureus
• Characterization of viral nanoparticles derived from mouse papillomavirus
• Effect of HBV protein HBx on activation of MEK1/2 signaling and inhibition of type I IFN in hepatoma cell line Huh7
• Non-covalent interactions of tryptophan in protein structure
• Response of primary photosynthetic processes in C3 and C4 monocotyledonous plants to steroids aplication
• Role of yeast WSS1 protease in DNA repair
• Study of exosomes in polyomavirus infection
• Vacuolar proteins in development of yeast colonies

Institute of Microbiology of the Czech Academy of Sciences

• Characterization of microorganisms with biodegradation potential for sulfonamides
• Domain 1.1 of the primary sigma factor and a new expression system forBacillus subtilis RNA polymerase
• Functional analysis of phosphoglucosamine mutase GlmM in Streptococcus pneumoniae
• Hybrid sigma factors of RNA polymerase in Corynebacterium glutamicum
• Identification of new substrates of Ser/Thr protein kinase StkP

Institute of Molecular Genetics of the Czech Academy of Sciences

• Development of advanced in-vivo imaging methods for non-invasive study of tumour growth dynamic
• Functional analysis of the TSSC4 chaperone during snRNP formation
• Identification of genes responsible for tumor induction with avian retroviruses subgroup J 
• Role of PML in ribosomal stress
• Stability of protein complexes in the cytoskeleton of the eukaryotic flagellum
• The role of histone modifications and gene expression in mouse spermatogenesis

Institute of Biotechnology of the Czech Academy of Sciences

• Basement membrane and the role of matrix metalloproteinases during embryonic wound healing
• Development and function of endocrine cells of the pancreas

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

• Modelling binding of insulin variants toward insulin receptor based on recent structural breakthroughs

Institute of Experimental Medicine of the Czech Academy of Sciences

• The study of the factors affecting colorectal cancer chemotherapy

National Institute of Public Health

• Analysis of circulating markers in patients with solid tumors

Faculties of Medicine, Charles University

• Analysis of mosaic chromosomal aberrations using various methods
• Colonization of human lung by non-pathogenic streptomycetes
• Gene expression of mutant alleles and X inactivation pattern in patients with selected X-linked disorders
• Proteomic analysis of myocardial integral membrane proteins

Crop Research Institute

• Gene pool of the secondary metabolism in soil bacterial communities

Institute of Animal Science

• Polymorphism of the transcription factor NF-κB and Toll-like receptor 2 in a production population of cattle (Bos taurus L.)