M.Sc. Theses Successfully Defended in the Academic Year 2008/2009

Due to the GDPR guidelines, the names of the respective students and supervisors are not listed here, only the titles of the respective theses (along with links to them -if available - in the Charles University Digital Repository, where you can find all relevant information). The theses are categorized according to the supervisor's institution and, within each institution, are sorted alphabetically. The majority of theses are written in Czech but all have at least an English abstract. Information on the current and past supervisory activities of individual internal members of the Department of Genetics and Microbiology can be found on the websites of the respective Laboratories.

Department of Genetics and Microbiology, Faculty of Science, Charles University

• Calcium binding sites outside of RTX domain in FrpC protein of Neisseria meningitidis
• Effect of environmental stresses on mutability of Bacillus subtilis - role of mismatch-repair system
• Evolution of the karyotype in two spider families, Atypidae and Pholcidae
• Exploitation of pseudocapsids for studies of functions of polyomavirus minor structural proteins VP2 and VP3
• Karyotype study of the spider infraorder Mygalomorphae (Araneae)
• Structure and function of IRES elements in yeast
• The introduction of novel polyomavirus model and study of the virus early phases
• Yeast as a tool in development of new antivirals

Institute of Microbiology of the Czech Academy of Sciences

• Analysis of the mutations in the HsdS recognition subunit of the R-M system EcoR124I altering subunit assembly
• Cancer treatment with polymer-bound cytostatic drugs and its potentiation through immunomodulation
• Functional analysis of the TIF32-HLD-PRT1-RRM-HCR1 module of the yeast translation initiation factor 3
• The role of saprotrophic basidiomycetes in soil fungal community (Význam saprotrofních basidiomycet ve společenstvu půdních hub)

Institute of Molecular Genetics of the Czech Academy of Sciences

• Alterations of the oncogenic properties of tumor cell lines by modulating oncogene expression. Example of v-src transformed chicken cell lines
• Establishment and phenotyping of three mouse congenic strains
• Genome-wide screening of sequences permitting long-term expression of integrated retroviruses: a new approach using RSV-induced tumors in chicken
• Patophysiological role of matrix metalloproteinase 19 in development of liver fibrosis
• Regulation of gene expression using a model of consomic mouse strains
• Sequence analysis of SIX homeobox family in Craspedacusta sowerbyi
• Targeting of genes of interest via avian retroviral receptor TVC
• The role of DNA damage in chemically induced senescence
• The role of JAK-STAT signalling pathway in cellular senescence

Institute of Biotechnology of the Czech Academy of Sciences

• The analysis of VDJ rearrangements and their role in the regulation of immunoglobulin production in CD19⁺IgM^+CD27^-CD21^lowCD38^lowCD24^+/- B cell population in CVID patients

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

• Study of the assembly and budding of mouse mammary tumor virus MMTV

Institute of Physiology of the Czech Academy of Sciences

• Characterization of calmodulin binding sites on TRP channels

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences

• The role of EGF-like proteins in oocyte meiotic resumption and cumulus cells expansion in the pig

Institute of Experimental Botany of the Czech Academy of Sciences

• Effect of 2,4,6-trinitrotoluene on the proteome of Arabidopsis thaliana

Other Supervisory Institutions

• Genetic diversity in genes important for survival of the domestic horse