Due to the GDPR guidelines, the names of the respective students are not listed here, only the individual supervisors (past and present members of the Laboratory) and titles of the respective theses (along with links to them - if available - in the Charles University Digital Repository). The theses are always listed according to their defense date (in descending order). Some of them are written in Czech but all have at least an English abstract.
Kateřina Bruštíková, Ph.D.
Alena Drda Morávková, Ph.D.
- Development of vaccines against porcine circovirus type 2
- Preparation of monoclonal antibodies against VP2 protein of human polyomaviruses
- Analysis of BK virus life cycle
- Construction of mouse polyomavirus chimeric VLP bearing melanoma epitopes
- Interaction of polyomaviruses with proteasomal system of host cell
- The introduction of novel polyomavirus model and study of the virus early phases
Assoc. Prof. Jitka Forstová, Ph.D.
- Polyomavirus minichromosomes: interactions with components of innate imunity
- Cellular factors restricting mouse polyomavirus infection in host cells: Studies of PML protein isoforms
- Interactions of mouse polyomavirus with Toll-like receptors
- Studies of polyomavirus trafficking from late endosomes towards the cell nucleus
- Studies of properties of the minor structural proteins of the Murine polyomavirus
- Preparation of expression vectors and virus mutants for studies of the minor structural proteins of polyomaviruses
- Studies of properties of gene products of the Merkel cell carcinoma polyomavirus: Antibody preparation and expression vector construction
- Preparation of monoclonal antibody against the major structural protein, VP1, of BK virus and construction of plasmids for protein interaction analysis by BiFC method
- Studies of minor capsid proteins of the mouse polyomavirus
- Exploitation of pseudocapsids for studies of functions of polyomavirus minor structural proteins VP2 and VP3
- Roles of cytoskeleton in mouse polyomavirus trafficking
- Preparation of monoclonal antibodies and expression plasmides for studies of properties of BKV structural proteins
- The late stage of mouse polyomavirus replication cycle: Preparation of methods for analysis of interactions of capsid protein, VP1, with nuclear cytoskeleton structures
- Development of viral and bacterial vehicles for antigen delivery into mammalian cells and their immunogenic properties
- Study of polyomaviruses:Preparation and characterisation of virus isolates and studies of the role of cellular cytoskeleton in virus trafficking to the cell nucleus
- Studies of early stages of the mouse polyomavirus infection
- Study of functions of VP2 and VP3 minor structural proteins of mouse polyomavirus
- Studies of delivery of the mouse polyomavirus genome into the cell nucleus
- Electron microscopy in analysis of mouse polyomavirus interactions with cellular structures
- Preparation of chimeric polyomavirus capsid structures for vaccination purposes
- Mouse polyomavirus virions: Interaction with cellular structures during virus entry and morphogenesis
- Study of mouse polyomavirus pseudocapsids
- Study of minor structural proteins of mouse polyomavirus
- Mouse polyomavirus: Study of the early phase of infection and the role of minor structural proteins
- Study of interactions between mouse polyomavirus antigens and host cell structures
- The impact of polyomavirus and its structural protein VP1 on the cytoskeleton and organization of selected nuclear proteins
- Artificial capsids of mouse polyomavirus and their interaction with the host cell
- Study of mouse polyomavirus entry into cells and interactions of the VP1 protein with cellular proteins
- Preparation of antibodies against the major structural protein of mouse polyomavirus
- Interactions of VP1 pseudocapsids and natural polyomavirus virions with cellular substructures: Electron microscopic analysis
- Preparation of monoclonal antibodies against structural domains of the VP1 protein of mouse polyomavirus
- Expression of mutated genes for the major structural protein VP1 of mouse polyomavirus in insect cells
- Polyomavirus major structural protein VP1: Production in selected eukaryotic expression systems for the study of Its properties in vitro and In cells
- Study of the function of minor structural antigens of polyomavirus
- Interaction of VP1, the major structural protein of polyomavirus, with DNA
- Preparation and analysis of capsid structures formed by late polyomavirus antigens synthesized in insect cells
- Production of the new human oncoprotein MN and its potential inducer NP (LCMV) in insect cells
Martin Fraiberk, Ph.D.
- Development of DNA vaccine against fish orthoreovirus 3 (PRV3)
- Replication of Merkel cell polyomavirus (MCPyV) in human cell lines *
Prof. Ivan Hirsch, Ph.D.
- Effect of HBV protein HBx on activation of MEK1/2 signaling and inhibition of type I IFN in hepatoma cell line Huh7
- Effect of small DNA viruses on regulation of interferon production
Lenka Horníková, Ph.D.
- Protein STING and its regulation during polyomavirus infection
- Analysis of serological cross-reactivity between antibodies against BK polyomavirus variants
- Regulation of STING function during murine polyomavirus infection
- The role of histone deacetylase 6 in murine polyomavirus replication cycle
- Major capsid protein of polyomaviruses and its interactions with nuclear lamins
- The role of proteins acetylation in life cycle of Polyomaviruses
- Major structural protein of Polyomaviruses: Interactions with host cell structures
- The role of posttranslational modifications of minor proteins and acetylation of microtubules in mouse polyomavirus infection
- Minor structural proteins of polyomaviruses: Attributes and interactions with cellular structures
Sandra Huerfano Meneses, Ph.D.
- Studies on the mechanisms of activation of the DNA sensor p204 during Mouse polyomavirus infection
- The effect of topoisomerase inhibitors on the activation of the DNA sensor cGAS
- Interactions of polyomavirus structures in the endoplasmic reticulum and on the path to the nucleus
Boris Rjabčenko, Ph.D.
Hana Španielová, Ph.D.
- Effect of polyhistidine modification of viral particles on their intracellular localization and gene delivery to the nucleus
- Targeting of viral nanoparticles to CD44 via hyaluronic acid
- Experimental system for production of IL-15 on viral carriers
- Development of a technique for gene transfer into T-lymphocytes using polyomavirus structures and the LAH4 peptide
- Preparation and characterization of modified viral particles derived from mouse polyomavirus for the transport of genes to increase the efficiency of transduction
- Analysis of antibody response during BK virus infection
- Characterization of viral nanoparticles derived from mouse papillomavirus
- Preparation of polyomaviral nanostructures for diagnostics of BK virus infections
- Utilization of mouse polyomavirus derived virus-like particles for cargo delivery into cells
- Directed evolution of mouse polyomavirus
- Optimization of methods for analysis of early steps of mouse polyomavirus life cycle
- Targetting prostate tumor cells by polyomavirus virus-like particles
- Experimental system for the mouse polyomavirus life cycle study
Vojtěch Šroller, Ph.D.
- Extracellular vesicles and middle T antigen of mouse polyomavirus
- Replication of Merkel cell polyomavirus (MCPyV) in human cell lines *
- Study of exosomes in polyomavirus infection
* ... supervisor from other Laboratory, co-supervisor from the Laboratory of Virology