Ph.D. Theses Successfully Defended in the Academic Year 2020/2021

Due to the GDPR guidlelines, the names of the respective students and supervisors are not listed here, only the titles of the respective theses (along with links to them in the Charles University Digital Repository, where you can find all relevant information). The theses are categorized according to the supervisor's institution and, within each institution, are sorted alphabetically. Some theses are written in Czech but all have at least an English abstract. Information on the current and past supervisory activities of individual internal members of the Department of Genetics and Microbiology can be found on the websites of the respective Laboratories.

Department of Genetics and Microbiology, Faculty of Science, Charles University

• Checkpoint blockade in cancer immunotherapy *
• Conformation of the adenylate cyclase toxin of Bordetella pertussis
• Differentiation of yeast colonies: The role of selected transcription factors and metabolic proteins
• Effect of small DNA viruses on function of plasmacytoid dendritic cells
• Modulation of plasmacytoid dendritic cell function: role of immunoreceptors TIM-3 and BDCA-2
• Mouse polyomavirus: The way of virus translocation to the cell nucleus and sensing of viral genomes by sensors of innate immunity
• Sensing of MPyV infection by innate immunity sensors
• Study of translation initiation factors of eIF4E protein family in relation to acute lymphoblastic leukemias and ontogenesis of Tribolium castaneum

Institute of Microbiology of the Czech Academy of Sciences

• Bacteria associated with decomposing deadwood
• Biosynthesis of propylproline building unit of lincomycin
• Factors affecting gene expression in Bacillus subtilis
• Integrated development of a bioprocess: From the soil enzyme to the yeast production platform
• Intracellular and intercellular regulation of gene expression in Gram-positive bacteria
• Regulation of transcription in Gram-positive bacteria
• Study of the key points of lincomycin and celesticetin biosynthesis
• The role of F₄₂₀H₂-dependent reductases in the biosynthesis of microbial bioactive metabolites incorporating a 4-alkyl-_L-proline derivate

Institute of Molecular Genetics of the Czech Academy of Sciences

• Genomic architecture and molecular mechanisms of hybrid sterility in mice
• Genotoxic stress and senescence in tumour cells: impact on the tumour growth and anti-tumour immunity
• Identification and characterisation of novel mechanisms regulating steady state and emergency granulopoiesis
• Male infertility and DNA germ cell breaks affected by the epigenetic factor PRDM9
• Mechanisms of phenotypic plasticity induced by genotoxic stress
• Retroviral variants and their relationship to nonpermisive cells

Institute of Biotechnology of the Czech Academy of Sciences

• Signalling pathways in pancreatic cancer and its treatment by targeting of mitochondria

Institute of Experimental Medicine of the Czech Academy of Sciences

• The use of "omics" methods in molecular-epidemiologic study in newborns from different localities of the Czech Republic

Institute of Physiology of the Czech Academy of Sciences

• Molecular mechanisms of entrainment of the fetal circadian clocks

Institute of Hematology and Blood Transfusion

• Small noncoding RNAs and their prognostic value in myelodysplastic syndromes

* ... thesis defended at the Department of Cell Biology, supervisor from the Department of Genetics and Microbiology