Ph.D. Theses Successfully Defended in the Academic Year 2018/2019

Due to the GDPR guidlelines, the names of the respective students and supervisors are not listed here, only the titles of the respective theses (along with links to them in the Charles University Digital Repository, where you can find all relevant information). The theses are categorized according to the supervisor's institution and, within each institution, are sorted alphabetically. Some theses are written in Czech but all have at least an English abstract. Information on the current and past supervisory activities of individual internal members of the Department of Genetics and Microbiology can be found on the websites of the respective Laboratories.

Department of Genetics and Microbiology, Faculty of Science, Charles University

• The expression of miRNA in HPV-associated and HPV-independent head and neck tumors

Institute of Microbiology of the Czech Academy of Sciences

• Bacterial RNA polymerase and molecules affecting its function
• Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes
• Factors interacting with bacterial RNA polymerase and their effect on the regulation of transcription initiation
• Interaction of nucleic acids with RNA polymerase
• Molecular details of translation reinitiation in budding yeast

Institute of Molecular Genetics of the Czech Academy of Sciences

• Determinants of the splice site selection in protein-coding and long non-coding RNAs
• Gene expression in chicken embryo: micromanipulation and visualization methods
• Genetic regulation of Leishmania infection
• Integration site distribution of expressed proviruses
• L1CAM and its role in cellular senescence
• Pathophysiological development and differentiation of cells during hematopoiesis
• Quality control in snRNP biogenesis

Institute of Biotechnology of the Czech Academy of Sciences

• Canonical and non-canonical signalling triggered by activated TRAIL receptors in human cells
• Mechanisms of resistance and iron metabolism in cancer stem cells
• Molecular bases of sensitivity to electron transport chain inhibition-induced cell death
• The effect of maternal diabetes on embryonic cardiovascular development and fetal programing
• The role of nitric oxide (NO) during Xenopus laevis embryonic epidermis development

Other Departments of the Faculty of Science, Charles University

• Splicing factors in the regulation of gene expression - the relationship between splicing and transcription in Saccharomyces cerevisiae