Ph.D. Theses Successfully Defended in the Academic Year 2015/2016

Due to the GDPR guidlelines, the names of the respective students and supervisors are not listed here, only the titles of the respective theses (along with links to them in the Charles University Digital Repository, where you can find all relevant information). The theses are categorized according to the supervisor's institution and, within each institution, are sorted alphabetically. Some theses are written in Czech but all have at least an English abstract. Information on the current and past supervisory activities of individual internal members of the Department of Genetics and Microbiology can be found on the websites of the respective Laboratories.

Department of Genetics and Microbiology, Faculty of Science, Charles University

• A study of the HCV IRES variability: An experimental approach coupled with design of a large-scale mutation database
• Function and localization of the SUN family of proteins in yeast populations

Institute of Microbiology of the Czech Academy of Sciences

• Combination of biochemical and high-throughput-sequencing approaches to study the role of Actinobacteria and fungi in the decomposition of plant biomass
• Divergent organohalide-respiring consortia in PCB-contaminated sediments
• Recognition of microbial patterns in earthworms
• Signaling effects of adenylate cyclase toxin action on phagocytes
• Signaling mechanism in nuclear reorientation and its functional singnificance in cell migration
• The role of alternative sigma factors of RNA polymerase in regulation of gene expression in Corynebacterium glutamicum
• The role of translation initiation factor 3 (eIF3) in translation termination

Institute of Molecular Genetics of the Czech Academy of Sciences

• Molecular mechanisms of physiological renewal and cancer transformation of mammalian gastrointestinal tissues
• Posttranslational modification of the adapter protein DAXX in the cellular response to genotoxic stress
• Structural studies of LEDGF/p75 interactions
• The role of Pax6 transcription factor in mouse eye development

Institute of Biotechnology of the Czech Academy of Sciences

• Increasing affinity of Interferon gamma receptor 1 to Interferon gamma by combining molecular modeling and experimental methods

Institute of Experimental Medicine of the Czech Academy of Sciences

• Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences

• Cytogenetics of selected groups of ray-finned fishes (Actinopterygii): Evolutionary-ecological questions associated with the dynamics of repetitive sequences and the occurrence of polyploidy

Institute of Experimental Botany of the Czech Academy of Sciences

• Mechanisms of DNA repair in the moss Physcomitrella patens
• Study of the DNA recombination mechanisms in plants

Institute of Endocrinology

• Study of genetic and infectious risk factors in the pathogenesis of obesity in Czech adolescents