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Understanding the Liver Fibrosis: Insights from Alagille Syndrome

Understanding the Liver Fibrosis: Insights from Alagille Syndrome

Published: Thursday 3.10.2024
What determines how much scar tissue one develops in the liver when suffering from liver disease (so-called fibrosis)?” A little fibrosis is normal and helps repair after injury, but often the fibrosis escalates, leading to liver failure. To answer this, researchers from Faculty of Science, Charles University, Jan Mašek, Ph.D. and colleagues, and Karolinska Institute studied a genetic disease called Alagille syndrome, which is characterized by surprisingly mild liver fibrosis despite severe liver disease (pericellular fibrosis instead of bridging).
Festive seminar opening the year of celebration of the 100th anniversary of the independence of the Department of Analytical Chemistry of the Faculty of Science of Charles University

Festive seminar opening the year of celebration of the 100th anniversary of the independence of the Department of Analytical Chemistry of the Faculty of Science of Charles University

Published: Monday 30.9.2024
On Tuesday, 23 September 2024, a festive seminar was held in the CH2 lecture hall of the Institute of Chemistry, Faculty of Science, to launch the year of celebrating the 100th anniversary. The seminar was held under the auspices of the Dean of the Faculty of Chemistry, Prof. Jiří Zima, and the Division of Analytical Chemistry of the European Chemical Society.
New Study Sheds Light on Ancient Protoribosome and its Role in Early Life Evolution

New Study Sheds Light on Ancient Protoribosome and its Role in Early Life Evolution

Published: Monday 30.9.2024
Scientists have uncovered new insights into the protoribosome, a molecular fossil within the ribosome, which plays a key role in the origin of life on Earth. This research, published in Nucleic Acids Research, could reshape our understanding of early ribosomal evolution and its significance for the development of life. One of the study´s lead researchers is Dr. Klára Hlouchová from department of Cell biology of the Faculty of Science, Charles University.
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