Protein MICAL1 Plays a Key Role in the Cellular Dynamics by Controlling the Cytoskeleton
Published: Wednesday 13.11.2024
Researchers have made a remarkable advancement in understanding how cells regulate their inner framework. The team from three institutes of the Czech Academy of Science, the Institute of Molecular Genetics, the Institute of Biotechnology and the Institute of Organic Chemistry and Biochemistry, the Faculty of Science of Charles University, BIOCEV and CEITEC has uncovered the precise molecular mechanisms behind the protein MICAL1, which plays a crucial role in maintaining cell shape and movement. Researchers' findings offer a detailed insight into MICAL1’s function in controlling actin filaments—the cell's flexible “skeleton”—and open up new possibilities for developing treatments to address diseases linked to MICAL dysfunction. The study was published by the prestigious journal Nature Communications.