Immunology

Offer of dissertation topics:

• Cancer Immunotherapy Based on Drug Delivery Systems for IDO Inhibitors in Combination with Chemotherapy
• Effect of gluten-free diet (GFD) on immune parameters, microbiome and metabolome in inflammatory bowel disease and primary sclerosing cholangitis
• Functional analysis of immune responses to acute myeloid leukemia
• Horizontal mitochondrial transfer and its regulation
• Characterization of Mouse Breast Milk and Maternal-Fetal Microchimerism Established During Lactation and Its Impact on Offspring's Immune System
• Intestinal bacteria – host cross-talk in growing juvenile host during chronic undernutrition and standard diet regime
• Intestinal barrier disruption as a consequence of modulation of Th17 pathway in obese psoriatic patients:mechanisms of action and microbiota involvement
• Mechanism of autoantigen egress from seminiferous tubules and establishment of immune tolerance in testes
• Mechanobiology of lymphocytes
• Microbial settlement of the gastrointestinal tract and its impact on the host
• Microbiome and regulation of food intake
• Modulation of antigen presentation to assess its effect on the establishment of central tolerance
• SRC-family kinases in the biology of T cells
• The link between the gut microbiome and synucleinopathy
• The role of dietary factors (e.g. gluten-free diet) on development and immune parameters in Parkinson's disease or other alfa-synucleinopathies e.g. Multiple System Atrophy (MSA).
• The role of myeloid cells in thymic T cell tolerance in health and disease
• Transcriptional control of chronic inflammation
• Transitional dendritic cells as new players in T cell tolerance
• Tumor Immunotherapy and Drug Delivery Systems: Utilization of siRNA and Activation of RIG-I and STING in Targeted Cancer Therapy

Profile of the graduate

The graduate's profile of the Doctoral Study Program (DSP) Parasitology is largely determined by the specific objectives of the doctoral thesis, which determines the nature of the training for independent scientific work or for practice in the field. The graduate has expertise in various parasitic organisms (e.g., protozoa, helminths, arthropods), especially their molecular biology, immunology and biochemistry, as well as their pathogenicity or epidemiology, all with an emphasis on host–parasite interaction. The graduate is able to solve theoretical and practical problems related to the research on parasites and parasitic diseases at multidisciplinary level, both in basic and applied research. Is well versed in the issues connected with the doctoral thesis and is able to solve theoretical and practical problems related to parasites at multidisciplinary level. The graduate is able to discuss with experts at the international level and to present achieved results in international journals and at scientific meetings. Is able to participate in international projects focused on parasitology or related disciplines and are ready to work at universities and research institutes, in education sector, health care or veterinary medicine, but also in state/governmental administration or in private (e.g., pharmaceutical or biotechnology companies), both in the Czech Republic and abroad.