RNDr. Roman Šolc, Ph.D.

Academic researcher

Lab of Molecular Anthropology

Research interests:

Human molecular cytogenetics: investigation of cryptic rearrangements of human chromosomes, particularly associated with bone dysplasia or mental retardation.

Didactics of biology: research on ways and effectiveness of teaching selected (“modern”) biological topics at Czech grammar schools.

Evolutionary and theoretical biology: evolution and history of evolutionary theories, creationism and its historical, social and philosophical connotations.

Research projects and grants:

Principal investigator:
GAUK 202615 Komplexní genetická analýza u pacientů s vybranými kostními dysplaziemi“ (2015–2016)

Co-worker:
IGA MZ NS/10327-3 Komplexní genetická analýza u pacientů s mentální retardací a dysmorfiemi – stanovení vhodného diagnostického postupu (2009–2011)

Teaching records:

Human cytogenetics I. (graduate course)
Human cytogenetics II. – methods (graduate course)
Human molecular cytogenetics (graduate course)
Practicum from Anthropology  (undergraduate course)
Recapitulation of biology III (undergraduate course)

Publications:

Vernerova, K., Solc, R. (2024) Biological determinants of the origin and development of the opposite psychological and behavioral traits associated with autism spectrum disorders and Williams syndrome. Research in Autism Spectrum Disorders, 118, 102479.

Jurisova, L., Solc, R. (2023) The role of cryptic rearrangements of human chromosomes in the etiology of schizophrenia. Journal of Genetics, 102(1), 30.

Kosuthova, K., Solc, R. (2023) Inversions on human chromosomes. American Journal of Medical Genetics Part A, 191(3), 672-683.

Hudec, M., Dankova, P., Solc, R., Bettazova, N., & Cerna, M. (2020). Epigenetic Regulation of Circadian Rhythm and Its Possible Role in Diabetes Mellitus. International Journal of Molecular Sciences, 21(8), 3005.

Hirschfeldova, K., & Solc, R. (2017). Comparison of SHOX and associated elements duplications distribution between patients (Lėri-Weill dyschondrosteosis/idiopathic short stature) and population sample. Gene, 627,164–168.

Solc, R., Klugerova, M., Vcelak, J., Baxova, A., Kuklik, M., Vseticka, J., Beharka, R., & Hirschfeldova, K. (2017). Mutation analysis of TRPS1 gene including core promoter, 5'UTR, and 3'UTR regulatory sequences with insight into their organization. Clinica Chimica Acta, 464, 30–36.

Solc, R. (2014). The Czech System of Evaluation of Science Research Handicaps Interdisciplinary Science. Knowledge Organization, 41(5), 410–413.

Solc, R., Hirschfeldova, K., Kebrdlova, V., & Baxova, A. (2014). Analysis of common SHOX gene sequence variants, and ~4.9kb PAR1 deletion in ISS patients. Journal of Genetics, 93(2), 505–508.

Hirschfeldova, K., Solc, R., Baxova, A., Zapletalova, J., Kebrdlova, V., Gaillyova, R., Prasilova, S., Soukalova, J., Mihalova, R., Lnenicka, P., Florianová, M., & Stekrova, J. (2012). SHOX gene defects and selected dysmorphic signs in patients of idiopathic short stature and Léri-Weill dyschondrosteosis. Gene, 491(2), 123–127.

Hirschfeldova, K., Baxova, A., Kebrdlova, V., Solc, R., Mihalova, R., Lnenicka, P., Vesela, K., Stekrova, J. (2011). Cryptic Chromosomal Rearrangements in Children with idiopathic mental retardation in the Czech population. Genetic Testing and Molecular Biomarkers, 15(9), 607–611.