Prezentace vybraných významných publikací členů naší katedry v posledních 10 letech. Aktuální a kompletní seznam publikací je možné vyhledat např. v databázích Web of Science nebo PubMed a zejména na webových stránkách jednotlivých výzkumných skupin.
2024
Parkash, V., Ashwin, H., Dey, S., & Layton, A. M. (2024). Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis. Nature Medicine, 29, 154-162. https://doi.org/10.1038/s41591-024-03146-9
Peña-Diaz, P., Braymer, J. J., Vacek, V., Zelená, M., Lometto, S., Mais, C. N., ... & Hampl, V. (2024). Characterization of the SUF FeS cluster synthesis machinery in the amitochondriate eukaryote Monocercomonoides exilis. Current Biology, 25, S0960-9822(24)00921-7. https://doi.org/10.1016/j.cub.2024.07.018
Peterková, K., Konečný, L., Macháček, T., Jedličková, L., Winkelmann, F., Sombetzki, M., & Dvořák, J. (2024). Winners vs. losers: Schistosoma mansoni intestinal and liver eggs exhibit striking differences in gene expression and immunogenicity. PLoS Pathogens, 20(5), e1012268. https://doi.org/10.1371/journal.ppat.1012268
Del Campo, J., Carlos-Oliveira, M., Čepička, I., Hehenberger, E., Horák, A., Karnkowska, A., ... & Hampl, V. (2023). The protist cultural renaissance. Trends in Microbiology, 32(2), 128-131. https://doi.org/10.1016/j.tim.2023.11.010
Schreiber, M., Macháček, T., Vajs, V., Šmídová, B., Majer, M., Hrdý, J., ... & Horák, P. (2024). Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti tapeworms. Frontiers in Immunology, 15, 1376907. https://doi.org/10.3389/fimmu.2024.1376907
2023
Macháček, T., Fuchs, C. D., Winkelmann, F., Frank, M., Scharnagl, H., Stojakovic, T., ... & Trauner, M. (2023). Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity. Liver International, 43(11), 2469-2478. https://doi.org/10.1111/liv.15710
Kachale, A., Pavlíková, Z., Nenarokova, A., Roithová, A., Durante, I. M., Miletínová, P., ... & Lukeš, J. (2023). Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment. Nature, 613(7945), 751-758. https://doi.org/10.1038/s41586-022-05584-2
Erban, T., Parizkova, K., Sopko, B., Talacko, P., Markovic, M., Jarosova, J., & Votypka, J. (2023). Imidacloprid increases the prevalence of the intestinal parasite Lotmaria passim in honey bee workers. Science of The Total Environment, 905, 166973. https://doi.org/10.1016/j.scitotenv.2023.166973
Treitli, S. C., Hanousková, P., Beneš, V., Brune, A., Čepička, I., & Hampl, V. (2023). Hydrogenotrophic methanogenesis is the key process in the obligately syntrophic consortium of the anaerobic ameba Pelomyxa schiedti. ISME Journal, 17(11), 1884-1894. https://doi.org/10.1038/s41396-023-01499-6
Novák, L. V., Treitli, S. C., Pyrih, J., Hałakuc, P., Pipaliya, S. V., Vacek, V., ... & Hampl, V. (2023). Genomics of preaxostyla flagellates illuminates the path towards the loss of mitochondria. PLoS Genetics, 19(12), e1011050. https://doi.org/10.1371/journal.pgen.1011050
Karnkowska, A., Yubuki, N., Maruyama, M., Yamaguchi, A., Kashiyama, Y., Suzaki, T., ... & Leander, B. S. (2023). Euglenozoan kleptoplasty illuminates the early evolution of photoendosymbiosis. Proceedings of the National Academy of Sciences, 120(12), e2220100120. https://doi.org/10.1073/pnas.2220100120
Votýpka J., Kolářová I., Horák P. (Hrsg.) (2023) Von Parasiten und Menschen. Springer Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65696-9
Votýpka J., Kolářová I., Horák P. a kol. (2023) O parazitech a lidech - 2., rozšířené vydání. Triton, Praha, 376 pp., ISBN 978-80-7684-209-0
Valigurová, A., & Kolářová, I. (2023). Unrevealing the mystery of latent leishmaniasis: What cells can host Leishmania? Pathogens, 12(2), 246. https://doi.org/10.3390/pathogens12020246
Jančarová, M., Polanská, N., Volf, P., & Dvořák, V. (2023). The role of sand flies as vectors of viruses other than phleboviruses. Journal of General Virology, 104(4), 001837. https://doi.org/10.1099/jgv.0.001837
Alexander, E. J. T., Salvemini, M., Sreenu, V. B., Hughes, J., Telleria, E. L., Ratinier, M., Arnaud, F., Volf, P., Brennan, B., Varjak, M., & Kohl, A. (2023). Characterisation of the antiviral RNA interference response to Toscana virus in sand fly cells. PLoS Pathogens, 19(3), e1011283. https://doi.org/10.1371/journal.ppat.1011283
Bussotti, G., Li, B., Pescher, P., Vojtkova, B., Louradour, I., Pružinová, K., Sadlova, J., Volf, P., & Späth, G. (2023). Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage. Proceedings of the National Academy of Sciences of the United States of America, 120(10), e2220828120. https://doi.org/10.1073/pnas.2220828120
Yanase, R., Moreira-Leite, F., Rea, E., Wilburn, L., Sadlova, J., Vojtkova, B., Pružinova, K., Taniguchi, A., Nonaka, S., Volf, P., & Sunter, J. D. (2023). Formation and three-dimensional architecture of Leishmania adhesion in the sand fly vector. eLife, 12, e84552. https://doi.org/10.7554/eLife.84552
2022
Záhonová, K., Treitli, S. C., Le, T., Škodová-Sveráková, I., Hanousková, P., Čepička, I., ... & Hampl, V. (2022). Anaerobic derivates of mitochondria and peroxisomes in the free-living amoeba Pelomyxa schiedti revealed by single-cell genomics. BMC Biology, 20(1), 56. https://doi.org/10.1186/s12915-022-01247-w
Zítek, J., Füssy, Z., Treitli, S. C., Peña-Diaz, P., Vaitová, Z., Zavadska, D., ... & Hampl, V. (2022). Reduced mitochondria provide an essential function for the cytosolic methionine cycle. Current Biology, 32(23), 5057-5068. https://doi.org/10.1016/j.cub.2022.10.028
Macháček, T., Leontovyč, R., Šmídová, B., Majer, M., Vondráček, O., Vojtěchová, I., ... & Horák, P. (2022). Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice. PLoS Pathogens, 18(2), e1010302. https://doi.org/10.1371/journal.ppat.1010302
Vojtechova, I., Machacek, T., Kristofikova, Z., Stuchlik, A., & Petrasek, T. (2022). Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity. PLoS Pathogens, 18(11), e1010929. https://doi.org/10.1371/journal.ppat.1010929
Lukeš, J., Kachale, A., Votýpka, J., Butenko, A., & Field, M. C. (2022). African trypanosome strategies for conquering new hosts and territories: the end of monophyly? Trends in Parasitology, 38(9), 724-736. https://doi.org/10.1016/j.pt.2022.05.011
Vondráček, O., Mikeš, L., Talacko, P., Leontovyč, R., Bulantová, J., & Horák, P. (2022). Differential proteomic analysis of laser-microdissected penetration glands of avian schistosome cercariae with a focus on proteins involved in host invasion. International Journal for Parasitology, 52(6), 343-358. https://doi.org/10.1016/j.ijpara.2021.12.003
Benallal, K. E., Garni, R., Harrat, Z., Volf, P., & Dvořák, V. (2022). Phlebotomine sand flies (Diptera: Psychodidae) of the Maghreb region: A systematic review of distribution, morphology, and role in the transmission of pathogens. PLoS Neglected Tropical Diseases, 16(1), e0009952. https://doi.org/10.1371/journal.pntd.0009952
Piel, L., Rajan, K. S., Bussotti, G., Varet, H., Legendre, R., Proux, C., Douche, T., Giai-Gianetto, Q., Chaze, T., Cokelaer, T., Vojtkova, B., Gordon-Bar, N., Doniger, T., Cohen-Chalamish, S., Rengaraj, P., Besse, C., Boland, A., Sadlova, J., … Späth, G. F. (2022). Experimental evolution links post-transcriptional regulation to Leishmania fitness gain. PLoS Pathogens, 18(3), e1010375. https://doi.org/10.1371/journal.ppat.1010375
2021
Kostygov, A. Y., Karnkowska, A., Votýpka, J., Tashyreva, D., Maciszewski, K., Yurchenko, V., & Lukeš, J. (2021). Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses. Open Biology, 11(3), 200407. https://doi.org/10.1098/rsob.200407
Ashwin, H., Sadlova, J., Vojtkova, B., Bečvář, T., Lypaczewski, P., Schwartz, E., Greensteed, E., Van Boxlaer, K., Parin, M., Lipinski, K. S., Parkash, V., Matlashewski, G., Layton, A. M., Lacey, C. J., Jaffe, C. L., Volf, P., & Kay, P. M. (2021). Characterization of a new Leishmania major strain for use in a controlled human infection model. Nature Communications, 12(1), 215. https://doi.org/10.1038/s41467-020-20569-3
Baker, N., Catta-Preta, C. M. C., Neish, R., Sadlova, J., Powell, B., Alves-Ferreira, ... Volf, P., & Mottram, J. C. (2021). Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival. Nature Communications, 12(1), 1244. https://doi.org/10.1038/s41467-021-21360-8
Bečvář, T., Vojtkova, B., Siriyasatien, P., Votýpka, J., Modrý, D., Jahn, P., Bates, P. A., Carpenter, S., Volf, P., & Sadlova, J. (2021). Experimental transmission of Leishmania (Mundinia) parasites by biting midges (Diptera: Ceratopogonidae). PLoS Pathogens, 17(2), e1009654. https://doi.org/10.1371/journal.ppat.1009654
2020
Novák Vanclová, A. M., Zoltner, M., Kelly, S., Soukal, P., Záhonová, K., Füssy, Z., ... & Hampl, V. (2020). Metabolic quirks and the colourful history of the Euglena gracilis secondary plastid. New Phytologist, 225(4), 1578-1592. https://doi.org/10.1111/nph.16237
Tomečková, L., Tomčala, A., Oborník, M., & Hampl, V. (2020). The lipid composition of Euglena gracilis middle plastid membrane resembles that of primary plastid envelopes. Plant Physiology, 184(4), 2052-2063. https://doi.org/10.1104/pp.20.00505
Lukeš J. & Votýpka J. (2020) Field Isolation and Cultivation of Trypanosomatids from Insects, 3–21. In: Michels P., Ginger M. & Zilberstein D. (eds.) Trypanosomatids. Methods in Molecular Biology, vol 2116. Humana, New York, NY, 823 pp. https://doi.org/10.1007/978-1-0716-0294-2_1
Dvořák, V., Kasap, O. E., Ivović, V., Mikov, O., Stefanovska, J., Martinković, F., … Alten, B. (2020). Sand flies (Diptera: Psychodidae) in eight Balkan countries: Historical review and region-wide entomological survey. Parasites & Vectors, 13(1), 573. https://doi.org/10.1186/s13071-020-04448-w
Halliday, C., Yanase, R., Catta-Preta, C. M. C., Moreira-Leite, F., Myšková, J., Pružinová, K., Volf, P., Mottram, J. C., & Sunter, J. D. (2020). Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis. PLoS Pathogens, 16(1), e1008494. https://doi.org/10.1371/journal.ppat.1008494
2019
Karnkowska, A., Treitli, S. C., Brzoň, O., Novák, L., Vacek, V., Soukal, P., ... & Hampl, V. (2019). The oxymonad genome displays canonical eukaryotic complexity in the absence of a mitochondrion. Molecular Biology and Evolution, 36(10), 2292-2312. https://doi.org/10.1093/molbev/msz147
International Helminth Genomes Consortium (2019). Comparative genomics of the major parasitic worms. Nature Genetics 51(1), 163-174. https://doi.org/10.1038/s41588-018-0262-1
Adl, S. M., Bass, D., Lane, C. E., Lukeš, J., Schoch, C. L., Smirnov, A., ... & Zhang, Q. (2019). Revisions to the classification, nomenclature, and diversity of eukaryotes. Journal of Eukaryotic Microbiology, 66(1), 4-119. https://doi.org/10.1111/jeu.12691
Treitli, S. C., Kolisko, M., Husník, F., Keeling, P. J., & Hampl, V. (2019). Revealing the metabolic capacity of Streblomastix strix and its bacterial symbionts using single-cell metagenomics. Proceedings of the National Academy of Sciences, 116(39), 19675-19684. https://doi.org/10.1073/pnas.1910793116
Hampl, V., Čepička, I., & Eliáš, M. (2019). Was the mitochondrion necessary to start eukaryogenesis? Trends in Microbiology, 27(2), 96-104. https://doi.org/10.1016/j.tim.2018.10.005
Jedličková, L., Dvořák, J., Hrachovinová, I., Ulrychová, L., Kašný, M., & Mikeš, L. (2019). A novel Kunitz protein with proposed dual function from Eudiplozoon nipponicum (Monogenea) impairs haemostasis and action of complement in vitro. International Journal for Parasitology, 49(5), 337-346. https://doi.org/10.1016/j.ijpara.2018.11.010
Ebenezer, T. E., Zoltner, M., Burrell, A., Nenarokova, A., Novák Vanclová, A. M., Prasad, B., ... & Field, M. C. (2019). Transcriptome, proteome and draft genome of Euglena gracilis. BMC Biology, 17, 1-23. https://doi.org/10.1186/s12915-019-0626-8
Jančarová, M., Bichaud, L., Hlaváčová, J., Priet, S., Ayhan, N., Spitzová, T., Volf, P., & Charrel, R. N. (2019). Experimental infection of sand flies by Massilia virus and viral transmission by co-feeding on sugar meal. Viruses, 11(4), 332. https://doi.org/10.3390/v11040332
Beneke, T., Demay, F., Hookway, E., Ashman, N., Jeffery, H., Smith, J., Valli, J., Bečvář, T., Myšková, J., Lestinova, T., Shafiq, S., Sadlova, J., Volf, P., & Wheeler, R. J. (2019). Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections. PLoS Pathogens, 15(3), e1007828. https://doi.org/10.1371/journal.ppat.1007828
Sunter, J. D., Yanase, R., Wang, Z. Y., Catta-Preta, C. M. C., Moreira-Leite, F., Myšková, J., Pružinová, K., Volf, P., Mottram, J. C., & Gull, K. (2019). Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host. Proceedings of the National Academy of Sciences of the United States of America, 116(14), 6351–6360. https://doi.org/10.1073/pnas.1815060116
2018
Vacek, V., Novák, L. V., Treitli, S. C., Táborský, P., Čepička, I., Kolísko, M., ... & Hampl, V. (2018). Fe–S cluster assembly in oxymonads and related protists. Molecular Biology and Evolution, 35(11), 2712-2718. https://doi.org/10.1093/molbev/msy168
Kazamia, E., Sutak, R., Paz-Yepes, J., Dorrell, R. G., Vieira, F. R. J., Mach, J., ... & Lesuisse, E. (2018). Endocytosis-mediated siderophore uptake as a strategy for Fe acquisition in diatoms. Science Advances, 4(5), eaar4536. https://doi.org/10.1126/sciadv.aar4536
Lukeš, J., Butenko, A., Hashimi, H., Maslov, D. A., Votýpka, J., & Yurchenko, V. (2018). Trypanosomatids are much more than just trypanosomes: clues from the expanded family tree. Trends in Parasitology, 34(6), 466-480. https://doi.org/10.1016/j.pt.2018.03.002
Grybchuk, D., Akopyants, N. S., Kostygov, A. Y., Konovalovas, A., Lye, L. F., Dobson, D. E., ... & Yurchenko, V. (2018). Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania. Proceedings of the National Academy of Sciences, 115(3), E506-E515. https://doi.org/10.1073/pnas.1717806115
Hadariová, L., Vesteg, M., Hampl, V., & Krajčovič, J. (2018). Reductive evolution of chloroplasts in non-photosynthetic plants, algae and protists. Current Genetics, 64, 365-387. https://doi.org/10.1007/s00294-017-0761-0
Dvořák, V., Shaw, J., & Volf, P. (2018). Parasite biology: The vectors. In Bruschi, F., & Gradoni, L. (Eds.), The leishmaniases: Old neglected tropical diseases (pp. 39–62). Springer. https://doi.org/10.1007/978-3-319-72386-0_3
Miglianico, M., Eldering, M., Slater, H., Ferguson, N., Ambrose, P., Lees, R. S., Koolen, K. M. J., Pružinová, K., Jančárová, M., Volf, P., Koenraadt, C. J. M., Duerr, H., Trevitt, G., Yang, B., Chatterjee, A. K., Wisler, J., Sturm, A., Bousema, T., Sauerwein, R. W., … Tremblay, M. S. (2018). Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases. Proceedings of the National Academy of Sciences of the United States of America, 115(28), E6920–E6926. https://doi.org/10.1073/pnas.1801338115
2017
Doehl, J. S., Sádlová, J., Aslan, H., Pružinová, K., Metangmo, S., Votýpka, J., ... & Smith, D. F. (2017). Leishmania HASP and SHERP genes are required for in vivo differentiation, parasite transmission and virulence attenuation in the host. PLoS Pathogens, 13(1), e1006130. https://doi.org/10.1371/journal.ppat.1006130
Akhoundi, M., Downing, T., Votýpka, J., Kuhls, K., Lukeš, J., Cannet, A., ... & Sereno, D. (2017). Leishmania infections: Molecular targets and diagnosis. Molecular aspects of medicine, 57, 1-29. https://doi.org/10.1016/j.mam.2016.11.012
Skalický, T., Dobáková, E., Wheeler, R. J., Tesařová, M., Flegontov, P., Jirsová, D., ... & Lukeš, J. (2017). Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid. Proceedings of the National Academy of Sciences, 114(44), 11757-11762. https://doi.org/10.1073/pnas.1712311114
Votýpka J., Modrý D., Oborník M., Šlapeta J. & Lukeš J. (2017) Apicomplexa (58 pp.) In: Archibald J.M., Simpson A.G.B. & Slamovits C.H. (eds.) Handbook of the Protists. Springer (1300 pp.) https://doi.org/10.1007/978-3-319-32669-6_20-1
Lestinova, T., Rohousova, I., Sima, M., de Oliveira, C. I., & Volf, P. (2017). Insights into the sand fly saliva: Blood-feeding and immune interactions between sand flies, hosts, and Leishmania. PLoS Neglected Tropical Diseases, 11(7), e0005600. https://doi.org/10.1371/journal.pntd.0005600
2016
Karnkowska, A., Vacek, V., Zubáčová, Z., Treitli, S. C., Petrželková, R., Eme, L., ... & Hampl, V. (2016). A eukaryote without a mitochondrial organelle. Current Biology, 26(10), 1274-1284. https://doi.org/10.1016/j.cub.2016.03.053
Akhoundi, M., Kuhls, K., Cannet, A., Votýpka, J., Marty, P., Delaunay, P., & Sereno, D. (2016). A historical overview of the classification, evolution, and dispersion of Leishmania parasites and sandflies. PLoS Neglected Tropical Diseases, 10(3), e0004349. https://doi.org/10.1371/journal.pntd.0004349
Leontovyč, R., Young, N. D., Korhonen, P. K., Hall, R. S., Tan, P., Mikeš, L., ... & Gasser, R. B. (2016). Comparative transcriptomic exploration reveals unique molecular adaptations of neuropathogenic Trichobilharzia to invade and parasitize its avian definitive host. PLoS Neglected Tropical Diseases, 10(2), e0004406. https://doi.org/10.1371/journal.pntd.0004406
Sima, M., Ferencova, B., Warburg, A., Rohousova, I., & Volf, P. (2016). Recombinant salivary proteins of Phlebotomus orientalis are suitable antigens to measure exposure of domestic animals to sand fly bites. PLoS Neglected Tropical Diseases, 10(3), e0004553. https://doi.org/10.1371/journal.pntd.0004553
2015
Horák, P., Mikeš, L., Lichtenbergová, L., Skála, V., Soldánová, M., & Brant, S. V. (2015). Avian schistosomes and outbreaks of cercarial dermatitis. Clinical Microbiology Reviews, 28(1), 165-190. https://doi.org/10.1128/cmr.00043-14
Votýpka, J., d’Avila-Levy, C. M., Grellier, P., Maslov, D. A., Lukeš, J., & Yurchenko, V. (2015). New approaches to systematics of Trypanosomatidae: criteria for taxonomic (re) description. Trends in Parasitology, 31(10), 460-469. https://doi.org/10.1016/j.pt.2015.06.015